Cases

Publication: February 8, 2022, Science online
Research Team: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Title: "Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody"

ANTcryo™ and UltrAuFoil grids were used to reveal the Omicron mutant strain's spike protein structure binding to the therapeutic antibody JMB2002 and receptor ACE2. The final resolutions achieved were 2.69 Å (using ANTcryo™) and 2.77 Å (using UltrAuFoil).

Publication: March 28, 2022
Research Team: Stanford University
Focus: Cryo-EM sample preparation and adrenergic receptor analysis

Comparative analysis using ANTcryo™ and Quantifoil grids for cryo-EM sample preparation. The study achieved resolutions of 2.49 Å with ANTcryo™ and 2.99 Å with Quantifoil, demonstrating superior performance of ANTcryo™ technology.

Publication: February 2020, Cell
Research Team: Liu Zhijie's team, ShanghaiTech University
Title: "Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures"

Analysis of three-dimensional cryo-EM structures of CB1 and CB2 bound to G protein molecules. The cryo-EM sample preparation used the ANTcryo™ grid (formerly CryoMatrix). Final resolutions achieved were 3.0 Å and 2.9 Å.