Peer-reviewed publications across structural biology, featuring Cell, Science, PNAS, and Cell Research. GPCR · Virus · Gene Editing · Antibody · Photosynthesis · Cilia/Flagella.
Shanghai Institute of Materia Medica, CAS · Xu H et al.
ANTcryo™ and UltrAuFoil grids were used to reveal the Omicron mutant strain spike protein structure binding to the therapeutic antibody JMB2002 and receptor ACE2. The final resolutions achieved were 2.69 Å (using ANTcryo™) and 2.77 Å (using UltrAuFoil), demonstrating superior resolution performance.
Stanford University
Comparative analysis using ANTcryo™ and Quantifoil grids for cryo-EM sample preparation. The study achieved resolutions of 2.49 Å with ANTcryo™ and 2.99 Å with Quantifoil, demonstrating superior performance of ANTcryo™ technology.
ShanghaiTech University · Liu ZJ et al.
Analysis of three-dimensional cryo-EM structures of CB1 and CB2 bound to G protein molecules. The cryo-EM sample preparation used the ANTcryo™ grid (formerly CryoMatrix). Final resolutions achieved: 3.0 Å and 2.9 Å.
Wang T, Liu ZJ et al. · ShanghaiTech University, iHuman Institute
The human olfactory receptor OR6A2 was successfully engineered into a functional protein for the first time, revealing its reversible covalent bond recognition mechanism for aldehyde odorants. A broadly conserved activation switch was discovered across Class II olfactory receptors.
S0092-8674(25)01430-8Xing L, Lu L et al. · Fudan University
First high-resolution structure of the early fusion intermediate of coronavirus S protein, revealing the precise conformation of the fusion peptide inserted into the host membrane after S2′ cleavage. Identifies this intermediate as an optimal antiviral target window.
DOI pendingXu P, Saito M, Zhang F et al. · Broad Institute / MIT
Structures of 13 Fanzor proteins from 3 different organisms reveal the molecular diversity of eukaryotic gene-editing systems. The ωRNA binding interface is highly conserved, while TAM recognition and catalytic sites vary. The RuvC domain "Lid" loop undergoes conformational change upon guide-DNA pairing to regulate activation.
S0092-8674(24)00844-4Rosen LE, Starr TN et al. (53 authors) · University of Utah / Vir Biotechnology
Discovery of human monoclonal antibody VIR-7229 with unprecedented cross-reactivity against all sarbecovirus clades, including non-ACE2 bat sarbecoviruses, while potently neutralizing all SARS-CoV-2 variants since 2019. VIR-7229 tolerates extreme epitope diversification via high-affinity binding, receptor molecular mimicry, and backbone interactions.
DOI: 10.1016/j.cell.2024.09.026Yan N, Yan C, Pan J et al. · Tsinghua University
First native structure of Chlamydomonas flagellar mastigonemes, revealing a complex assembly mediated by polysaccharides. Elucidates the molecular basis of ciliary motility and mechanosensation — the only cilia/flagella structural biology work in the collection.
DOI: 10.1016/j.cell.2024.03.005Liu ZJ et al. · ShanghaiTech University
Three-dimensional cryo-EM structures of CB1 and CB2 bound to G protein molecules. Cryo-EM sample preparation used the ANTcryo™ grid. Final resolutions: 3.0 Å and 2.9 Å.
DOI: 10.1016/j.cell.2020.01.007Jin W, Xu RM et al. · Institute of Biophysics, CAS
Reveals the DNA targeting mechanism of human LINE-1, the only autonomously active retrotransposon. ORF2p functions as a structure-dependent endonuclease, binding upstream dsDNA and recognizing downstream fork/flap structures, suggesting L1 transposition "piggybacks" on chromosomal processes with non-canonical DNA structures.
DOI: 10.1126/science.adu3433Shen L, Wang W et al. · Institute of Botany, CAS
Coccolithophore PSI-fucoxanthin supercomplex at 2.79 Å resolution — 38 peripheral FCPI antennas, 819 pigment molecules, 95% quantum efficiency. Demonstrates ANTcryo™ capability for resolving ultra-large membrane protein complexes.
DOI: 10.1126/science.adv2132Peng R, Chang YW et al. · University of Pennsylvania
First revelation of influenza virus RNP as a right-handed antiparallel double helix with viral RNA wrapped in the minor groove. Visualized conformational changes of viral polymerase across functional states; nucleoprotein tail loop identified as a key drug target with candidate lead compounds.
DOI: 10.1126/science.adq7597Xu H et al. · Shanghai Institute of Materia Medica, CAS
ANTcryo™ and UltrAuFoil grids were used to reveal the Omicron mutant strain spike protein structure binding to therapeutic antibody JMB2002 and receptor ACE2. Resolutions: 2.69 Å (ANTcryo™) vs 2.77 Å (UltrAuFoil).
Wu B et al. · Shanghai Institute of Materia Medica, CAS
Cryo-EM structures of the glucagon receptor in complex with Gs and various ligands, providing a structural framework for understanding class B GPCR activation and rational drug design.
DOI: 10.1126/science.aaz5346Kobilka B et al. · Stanford University
A novel calcineurin-fusion strategy for GPCR structural biology, enabling high-resolution cryo-EM studies. Represents the first ANTcryo™ publication from a leading international structural biology lab.
DOI: 10.1073/pnas.2414544121Sun D, Xu HE, Tian C et al. · University of Science and Technology of China
First high-resolution structure (2.65–2.88 Å) of a GPCR–β-arrestin1–biased allosteric modulator SBI-553 ternary complex. Discovered a novel "loop engagement" coupling mode — NTSR1 ICL3 binds the central crest cavity of β-arrestin1, representing a previously unobserved arrestin-selective GPCR conformation.
DOI: 10.1038/s41422-025-01095-7Huang F et al. · Institute of Biophysics, CAS
The foundational paper introducing the amorphous nickel-titanium alloy (ANTA) film as a revolutionary non-carbon support for cryo-EM. Demonstrated 18× lower protein adsorption, superior conductivity, and 2.36 Å resolution.
Data sourced from public ANTcryo™ user achievement records and verified against publisher databases. ANTcryo™ has supported dozens of high-impact publications — this list represents a curated selection.